これまでの研究業績、出版物

[原著論文]

Yuji Sato, Yoko Iijima, Mohamed Darwish, Tadayuki Sato and Takatoshi Iijima.

Distinct Expression of SLM2 Underlies Splicing-Dependent Trans-Synaptic Signaling of Neurexin Across GABAergic Neuron Subtypes.

Neurochemical Research (2021) doi: 10.1007/s11064-021-03384-0.

(T.I. is a corresponding author)

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Takatoshi Iijima and Takeshi Yoshimura.

A Perspective on the Role of Dynamic Alternative RNA Splicing in the Development, Specification, and Function of Axon Initial Segment.

Frontiers in Molecular Neuroscience. 12:295 (2019) doi.org/10.3389/fnmol.2019.00295.

(T.I. is a corresponding author)

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Yoko Iijima, Masami Tanaka, Satoko Suzuki, David Hauser, Masayuki Tanaka, Chisa Okada, Masatoshi Ito, Noriko Ayukawa, Yuji Sato, Masato Ohtsuka, Peter Scheiffele and Takatoshi Iijima.

SAM68-Specific Splicing Is Required for Proper Selection of Alternative 3' UTR Isoforms in the Nervous System.

iScience. 22:318-335. (2019) doi: 10.1016/j.isci.2019.11.028.

(Y.I, M.T. and S.S. are contributed equally.; T.I. is a corresponding author)

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Yuji Sato, Satoko Suzuki, Yoko Iijima, and Takatoshi Iijima.

Neuroligin-induced presynaptic differentiation through SLM2-mediated splicing modifications of Neurexin in cerebellar cultures.

Biochemical and Biophysical Research Communications. 493(2)1030-1036. (2017) doi: 10.1016/j.bbrc.2017.09.097.

(T.I. is a corresponding author)

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Satoko Suzuki, Noriko Ayukawa, Chisa Okada, Masami Tanaka, Susumu Takekoshi, Yoko Iijima, and Takatoshi Iijima.

Spatio-temporal and dynamic regulation of neurofascin alternative splicing in mouse cerebellar neurons.

Scientific Reports 7:11405 (2017) doi: 10.1038/s41598-017-11319-5. (T.I. is a corresponding author)

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 Yoko Iijima, Katharina Behr, Takatoshi Iijima, Barbara Biemanns, Josef Bischofberger and Peter Scheiffele.

Distinct Defects in Synaptic Differentiation of Neocortical Neurons in Response to Prenatal Valproate Exposure.

Scientific Reports 6:27400 (2016) doi: 10.1038/srep27400.

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Takatoshi Iijima, Chiharu Hidaka and Yoko Iijima.

Update Article: Spatio-temporal regulations and functions of neuronal alternative RNA splicing in developing and adult brains.

Neuroscience Research. 109:1-8 (2016) doi: 10.1016/j.neures.2016.01.010.

(T.I. is a corresponding author)

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Yoko Hanno-Iijima, Masami Tanaka and Takatoshi Iijima.

Activity-dependent bidirectional regulation of GAD expression in a homeostatic fashion is mediated by BDNF-dependent and independent pathways.

PLoS ONE 10(8): e0134296 (2015) doi: 10.1371/journal.pone.0134296.

(T.I. is a corresponding author)

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Takatoshi Iijima, Yoko Hanno-Iijima, Harald Witte and Peter Scheiffele.

Neuronal cell-type specific alternative splicing is regulated by the KH-domain protein SLM1

The Journal of Cell Biology 204: 331-342 (2014). doi: 10.1083/jcb.201310136.

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Peter Scheiffele and Takatoshi Iijima.

Choreographing the axo-dendritic dance.

Developmental Cell 23: 923-924 (2012) doi: 10.1016/j.devcel.2012.10.020.

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Takatoshi Iijima, Karen Wu, Harald Witte, Yoko Hanno-Iijima, Timo Glatter, Stephane Richard and Peter Scheiffele.

SAM68 regulates neuronal activity-dependent alternative splicing of Neurexin-1.

Cell 147: 1601-1615 (2011) doi: 10.1016/j.cell.2011.11.028.

(Featured as a "Must Read" paper on Faculty of 1000 Biology)

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Peter Scheiffele, Takatoshi Iijima, Harald Witte, Karen Wu, Fatiha Boukhtouche, Anna Kalinovsky.

Molecular mechanisms of synaptic differentiation and selective synapse assembly.

International Journal of Developmental Neuroscience 28: 639-640. (2010)

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Takatoshi Iijima, Eriko Miura, Masahiko Watanabe and Michisuke Yuzaki.

Distinct expression of C1q-like family mRNAs in mouse brain and biochemical characterization of their encoded proteins.

European Journal of Neuroscience 31: 1606-1615 (2010) doi: 10.1111/j.1460-9568.2010.07202.x.

(T.I. and E.M. equally contribute to this work)

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Takatoshi Iijima, Kyoichi Emi and Michisuke Yuzaki.

Activity-dependent repression of Cbln1 expression: Mechanism for developmental and homeostatic regulation of synapses in cerebellum.

The Journal of Neuroscience 29: 5425-5435 (2009) doi: 10.1523/JNEUROSCI.4473-08.2009.

Keiko Matsuda, Tetsuro Kondo, Takatoshi Iijima, Shinji Matsuda, Masahiko Watanabe and Michisuke Yuzaki.

Cbln1 binds to specific postsynaptic sites at parallel fiber–Purkinje cell synapses in the cerebellum.

European Journal of Neuroscience 29: 707-717 (2009) doi: 10.1111/j.1460-9568.2009.06639.x.

Aya Ito-Ishida, Eriko Miura, Kyoichi Emi, Takatoshi Iijima, Keiko Matsuda, Tetsuro Kondo, Masahiko Watanabe and Michisuke Yuzaki.

Cbln1 regulates rapid Formation and maintenance of excitatory synapses in mature cerebellar Purkinje cells in vitro and in vivo.

The Journal of Neuroscience 28: 5920-5930 (2008) doi: 10.1523/JNEUROSCI.1030-08.2008.

Takatoshi Iijima, Hiroo Ogura, Kanako Takatsuki, Shigenori Kawahara, Kenichiro Wakabayashi, Daisuke Nakayama, Masato Fujioka, Yuki Kimura, Alan Bernstein, Hirotaka James Okano, Yutaka Kirino and Hideyuki Okano.

Impaired motor functions in mice lacking the RNA-binding protein Hzf.

Neuroscience Research. 58: 183-189 (2007)

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Takatoshi Iijima, Eriko Miura, Keiko Matsuda, Yuichi Kamekawa, Masahiko Watanabe and Michisuke Yuzaki.

Characterization of a transneuronal cytokine family Cbln - Regulation of secretion by heteromeric assembly.

European Journal of Neuroscience. 25: 1049-1057 (2007)

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Eriko Miura, Takatoshi Iijima, Michisuke Yuzaki and Masahiko Watanabe.

Distinct expression of Cbln family in developing and adult brain.

European Journal of Neuroscience. 24: 750-760 (2006)

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Takatoshi Iijima, Takao Imai, Hirotaka James Okano, Yuki Kimura, Alan Bernstein, Michisuke Yuzaki and Hideyuki Okano.

Hzf protein regulates dendritic localization and BDNF-induced translation of type1 Inositol 1,4,5-trisphosphate receptor mRNA.

Proceedings of the National Academy Sciences of the United States of America. 102: 17190-17195 (2005)

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Hiroshi Mori, Shin-ichiro Sakakibara, Takao Imai, Yuki Nakamura, Takatoshi Iijima, Akira Suzuki, Yoshihiro Yuasa, Masatoshi Takeda and Hideyuki Okano.

Expression of mouse igf2 mRNA-binding protein 3 and its implications for the developing central nervous system.

Journal of Neuroscience Research 64: 132-143 (2001)

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山本直敬, 飯島崇利, 一宮慎吾, 影山肇, 木村秀樹, 中河原章

「肺癌におけるp53関連遺伝子p73の変異および欠失とその臨床的意義」

日本外科学会雑誌, 100, 512 (1999)

[日本語総説]

1. 飯島崇利：日本神経化学会奨励賞受賞者研究紹介「神経細胞の分化と可塑性を司るRNA制御機構」

神経化学 52 (3): 48-52 (2014)

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2. 飯島崇利：ミニレビュー「神経活動に依存的な選択的スプライシング機構と役割」

生化学 85 (7) : 570-574 (2013)

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3. 飯島崇利：Current topics「RNA結合タンパク質SAM68はシナプス形成因子Neurexin-1の選択的スプライシングを神経活動依存的に制御する」：実験医学 30 (9) : 1439-1443 (2012)

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4. 松田恵子, 飯島崇利, 石田綾, 柚崎通介：特集―いまシナプスで何が起きているか？：記憶・学習そして精神・神経疾患としての新しいシナプス像　「シナプス前部から分泌されるシナプス形成因子」

細胞工学 28 (9) : 880-885 (2009)

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5. 飯島崇利：Cutting edge「樹状突起へmRNAを輸送するタンパク質」：

Medical Science Digest 34 (2) : 2-3（2008）

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6. 飯島崇利, 岡野栄之：特集―翻訳制御のダイナミクスを解く「樹状突起における局所的翻訳機構」

実験医学 25 (1) : 39-44 (2007)

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7. 飯島崇利, 松田恵子、柚崎通介：特集―RIの逆襲「シナプス可塑性研究におけるアイソトープの活用」

細胞工学 26 (4) : 320-327 (2007)

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8. 飯島崇利，岡野栄之：「幹細胞システムを用いた中枢神経の再生医学」

神経研究の進歩 47 (6) : 841-849 (2003)