これまでの主な研究業績、出版物
（筆頭著者、最終著者のみ。詳しくはResearchmapを参照してください。）

[原著論文]

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Yoko Hanno, Moe Nakanishi, Akinori Takase, Jun Nomura, Masami Tanaka, Yumi Iida, Masayuki Tanaka, Hiroyuki Hosokawa, Masatoshi Ito, Katsunaka Mikami, Katsuto Hozumi, Goichi Miyoshi, Toru Takumi, and Takatoshi Iijima. Targeting Notch Signaling to Restore Neural Development and Behavior in Autism.

https://doi.org/10.21203/rs.3.rs-6343474/v1.

(T.I. is a corresponding author)

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Mohamed Darwish, Satoko Suzuki, Yuki Ogawa, Akinori Takase, Masami Tanaka, Yoko Iijima, Yuji Sato, Mariko Suzuki, Yumi Kanegae, Chisa Okada, Masayuki Takana, Hirotaka-James Okano, Hiroshi Kuba and Takatoshi Iijima. Neuronal activity-regulated micro-exon splicing underlies late-onset plasticity at the axon initial segment.　

BioRxiv. https://doi.org/10.1101/2023.10.29.564567.

(T.I. is a corresponding author))

 

Mohamed Darwish, Masatoshi Ito, Yoko Iijima, Akinori Takase, Noriko Ayukawa, Satoko Suzuki, Masami Tanaka, Kanae Komori, Daisuke Kaida and Takatoshi Iijima.

Neuronal SAM68 regulates alternative last exon splicing and ensures proper synapse development and function. Journal of Biological Chemistry. (2023) 299 (10):105168. doi: 10.1016/j.jbc.2023.105168. 

 

Yuji Sato, Yoko Iijima, Mohamed Darwish, Tadayuki Sato and Takatoshi Iijima.

Distinct Expression of SLM2 Underlies Splicing-Dependent Trans-Synaptic Signaling of Neurexin Across GABAergic Neuron Subtypes.

Neurochemical Research (2021) doi: 10.1007/s11064-021-03384-0.

(T.I. is a corresponding author)

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Takatoshi Iijima and Takeshi Yoshimura.

A Perspective on the Role of Dynamic Alternative RNA Splicing in the Development, Specification, and Function of Axon Initial Segment.

Frontiers in Molecular Neuroscience. 12:295 (2019) doi.org/10.3389/fnmol.2019.00295.

(T.I. is a corresponding author)

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Yoko Iijima, Masami Tanaka, Satoko Suzuki, David Hauser, Masayuki Tanaka, Chisa Okada, Masatoshi Ito, Noriko Ayukawa, Yuji Sato, Masato Ohtsuka, Peter Scheiffele and Takatoshi Iijima.

SAM68-Specific Splicing Is Required for Proper Selection of Alternative 3' UTR Isoforms in the Nervous System.

iScience. 22:318-335. (2019) doi: 10.1016/j.isci.2019.11.028.

(Y.I, M.T. and S.S. are contributed equally.; T.I. is a corresponding author)

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Yuji Sato, Satoko Suzuki, Yoko Iijima, and Takatoshi Iijima.

Neuroligin-induced presynaptic differentiation through SLM2-mediated splicing modifications of Neurexin in cerebellar cultures.

Biochemical and Biophysical Research Communications. 493(2)1030-1036. (2017) doi: 10.1016/j.bbrc.2017.09.097.

(T.I. is a corresponding author)

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Satoko Suzuki, Noriko Ayukawa, Chisa Okada, Masami Tanaka, Susumu Takekoshi, Yoko Iijima, and Takatoshi Iijima.

Spatio-temporal and dynamic regulation of neurofascin alternative splicing in mouse cerebellar neurons.

Scientific Reports 7:11405 (2017) doi: 10.1038/s41598-017-11319-5.

(T.I. is a corresponding author)

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 Yoko Iijima, Katharina Behr, Takatoshi Iijima, Barbara Biemanns, Josef Bischofberger and Peter Scheiffele.

Distinct Defects in Synaptic Differentiation of Neocortical Neurons in Response to Prenatal Valproate Exposure.

Scientific Reports 6:27400 (2016) doi: 10.1038/srep27400.

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Takatoshi Iijima, Chiharu Hidaka and Yoko Iijima.

Update Article: Spatio-temporal regulations and functions of neuronal alternative RNA splicing in developing and adult brains.

Neuroscience Research. 109:1-8 (2016) doi: 10.1016/j.neures.2016.01.010.

(T.I. is a corresponding author)

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Yoko Hanno-Iijima, Masami Tanaka and Takatoshi Iijima.

Activity-dependent bidirectional regulation of GAD expression in a homeostatic fashion is mediated by BDNF-dependent and independent pathways.

PLoS ONE 10(8): e0134296 (2015) doi: 10.1371/journal.pone.0134296.

(T.I. is a corresponding author)

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Takatoshi Iijima, Yoko Hanno-Iijima, Harald Witte and Peter Scheiffele.

Neuronal cell-type specific alternative splicing is regulated by the KH-domain protein SLM1

The Journal of Cell Biology 204: 331-342 (2014). doi: 10.1083/jcb.201310136.

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Peter Scheiffele and Takatoshi Iijima.

Choreographing the axo-dendritic dance.

Developmental Cell 23: 923-924 (2012) doi: 10.1016/j.devcel.2012.10.020.

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Takatoshi Iijima, Karen Wu, Harald Witte, Yoko Hanno-Iijima, Timo Glatter, Stephane Richard and Peter Scheiffele.

SAM68 regulates neuronal activity-dependent alternative splicing of Neurexin-1.

Cell 147: 1601-1615 (2011) doi: 10.1016/j.cell.2011.11.028.

(Featured as a "Must Read" paper on Faculty of 1000 Biology)​

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Takatoshi Iijima, Eriko Miura, Masahiko Watanabe and Michisuke Yuzaki.

Distinct expression of C1q-like family mRNAs in mouse brain and biochemical characterization of their encoded proteins.

European Journal of Neuroscience 31: 1606-1615 (2010) doi: 10.1111/j.1460-9568.2010.07202.x.

(T.I. and E.M. equally contribute to this work)

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Takatoshi Iijima, Kyoichi Emi and Michisuke Yuzaki.

Activity-dependent repression of Cbln1 expression: Mechanism for developmental and homeostatic regulation of synapses in cerebellum.

The Journal of Neuroscience 29: 5425-5435 (2009) doi: 10.1523/JNEUROSCI.4473-08.2009.

 

Takatoshi Iijima, Hiroo Ogura, Kanako Takatsuki, Shigenori Kawahara, Kenichiro Wakabayashi, Daisuke Nakayama, Masato Fujioka, Yuki Kimura, Alan Bernstein, Hirotaka James Okano, Yutaka Kirino and Hideyuki Okano.

Impaired motor functions in mice lacking the RNA-binding protein Hzf.

Neuroscience Research. 58: 183-189 (2007)

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Takatoshi Iijima, Eriko Miura, Keiko Matsuda, Yuichi Kamekawa, Masahiko Watanabe and Michisuke Yuzaki.

Characterization of a transneuronal cytokine family Cbln - Regulation of secretion by heteromeric assembly.

European Journal of Neuroscience. 25: 1049-1057 (2007)

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Eriko Miura, Takatoshi Iijima, Michisuke Yuzaki and Masahiko Watanabe.

Distinct expression of Cbln family in developing and adult brain.

European Journal of Neuroscience. 24: 750-760 (2006)

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Takatoshi Iijima, Takao Imai, Hirotaka James Okano, Yuki Kimura, Alan Bernstein, Michisuke Yuzaki and Hideyuki Okano.

Hzf protein regulates dendritic localization and BDNF-induced translation of type1 Inositol 1,4,5-trisphosphate receptor mRNA.

Proceedings of the National Academy Sciences of the United States of America. 102: 17190-17195 (2005)

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[日本語総説]

 

飯島崇利：特集―mRNAスプライシング制御の最前線と創薬への応用

「神経ネットワークと可塑性を支配するダイナミックなスプライシング制御—メカニズムの理解から創薬に向けて」

生化学94(6): 852-860 (2022) doi:10.14952/SEIKAGAKU.2022.940852

 

飯島崇利：日本神経化学会奨励賞受賞者研究紹介「神経細胞の分化と可塑性を司るRNA制御機構」

神経化学 52 (3): 48-52 (2014)

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飯島崇利：ミニレビュー「神経活動に依存的な選択的スプライシング機構と役割」

生化学 85 (7) : 570-574 (2013)

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飯島崇利：Current topics「RNA結合タンパク質SAM68はシナプス形成因子Neurexin-1の選択的スプライシングを神経活動依存的に制御する」：実験医学 30 (9) : 1439-1443 (2012)

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松田恵子, 飯島崇利, 石田綾, 柚崎通介：特集―いまシナプスで何が起きているか？：記憶・学習そして精神・神経疾患としての新しいシナプス像　「シナプス前部から分泌されるシナプス形成因子」

細胞工学 28 (9) : 880-885 (2009)

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5飯島崇利：Cutting edge「樹状突起へmRNAを輸送するタンパク質」：

Medical Science Digest 34 (2) : 2-3（2008）

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飯島崇利, 岡野栄之：特集―翻訳制御のダイナミクスを解く「樹状突起における局所的翻訳機構」

実験医学 25 (1) : 39-44 (2007)

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飯島崇利, 松田恵子、柚崎通介：特集―RIの逆襲「シナプス可塑性研究におけるアイソトープの活用」

細胞工学 26 (4) : 320-327 (2007)

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飯島崇利，岡野栄之：「幹細胞システムを用いた中枢神経の再生医学」

神経研究の進歩 47 (6) : 841-849 (2003)